Potential Mechanism of Maslinic Acid against Hypolipidemia Based on Network Pharmacology and Molecular Docking Integration Strategy

Maslinic acid is a pentacyclic triterpenoid acid. Recent research has shown that it various biological activities such as anti-tumor, hypoglycaemic and hypolipidemic. Among them, the hypolipidemic effect prominent this study aims to further explore its mechanism of action in treatment hyperlipidemia. The chemical structure maslinic was obtained from PubChem. Based on structure, bioavailability drug-like properties were analyzed using Swiss absorption, distribution, metabolism excretion potential targets SwissTargetPrediction PharmMapper. Then, differentially expressed genes between hyperlipidemia patients health group through gene expression omnibus data set, related complemented DrugBank, online Mendelian inheritance man, GeneCards, DisGeNET therapeutic target databases. protein-protein interaction network constructed, CytoNCA plugin VarElect used screen core metascape systematically analyze mechanism. Finally, molecular docking showcased model. A total 288 289 hyperlipidemia-related collected 18 found. enrichment analysis results explained can treat complex interactions which regulation including albumin, peroxisome proliferator activated receptor alpha apolipoprotein, signaling pathway play major role.